Manual therapy reduces pain, disability and oxidative stress in patients with chronic non-specific neck pain: a double-blind, randomized pilot study (pubmed.ncbi.nlm.nih.gov)

• Manual therapy significantly improved pain and disability.
• Oxidative stress markers (MDA, GPx, SOD) showed significant changes.
• Double-blind randomized design enhances evidence quality.

"A double-blind, randomized pilot study investigated the effect of manual therapy on pain, disability and oxidative stress in chronic non-specific neck pain. Results showed significant reductions in all three parameters compared to sham therapy. The study suggests manual therapy not only improves clinical symptoms but also influences systemic oxidative stress markers. Further research with larger samples is needed."