Objectively measured reallocation of time to MVPA or sleep associated with lower hip/knee OA incidence in UK Biobank (bmjopensem.bmj.com)

• Reallocating 30 min/day to MVPA from sedentary or light activity reduced hip/knee OA risk by 2-6%.
• Reallocating 30 min/day to sleep from sedentary or light activity reduced OA risk by 3-7%.
• Reallocating time to light physical activity increased OA risk (HR up to 1.07).
• Benefits were stronger in overweight/obese for MVPA and in leaner individuals for sleep.

"This prospective UK Biobank study of 85,706 adults used wrist-worn accelerometers to examine how 24-hour movement behaviours relate to hip and knee osteoarthritis incidence over 7.6 years. Compositional Cox models showed that reallocating 30 minutes/day from sedentary time or light activity to moderate-to-vigorous physical activity (MVPA) or sleep significantly reduced OA risk. Conversely, reallocating time to light activity increased risk. Findings support personalised 24-hour movement guidelines for OA prevention, with stronger effects in overweight/obese individuals for MVPA and in leaner individuals for sleep."